Clinical MPM Supplementary Data

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This website provides the supplementary data for the paper entitled “Quantitative‌ ‌Multi-Parameter‌ ‌Mapping‌ ‌Optimized‌ ‌for‌ ‌the‌ ‌Clinical‌ ‌Routine‌”. If you use the data in your analyses, please use the following citation:

Cooper G, Hirsch S, Scheel M, Brandt AU, Paul F, Finke C, Boehm-Sturm P and Hetzer S (2020) Quantitative Multi-Parameter Mapping Optimized for the Clinical Routine. Front. Neurosci. 14:611194. doi: 10.3389/fnins.2020.611194

Using a short protocol adapted for clinical studies at 1.6 mm isotropic resolution, we measured magnetisation transfer ratio (MT), effective proton density (PD), longitudinal relaxation rate (R1) and effective transverse relaxation rate (R2*) in six healthy participants with three repetitions.

We calculated the intra-subject and inter-subject reliability of each map in every region of the Neuromorphometrics atlas.

The intra-subject (scan-rescan) reliability data can be seen here: intra-subject reliability

The inter-subject reliability data can be seen here: inter-subject reliability

Additionally we assessed the intra-subject reliability of one subject scanned three times at multiple resolutions. The data for this analysis can be seen here: multi-resolution analysis

You can download all the reliability data, mean parameter values, the multi-resolution analysis results, the bash scripts for MPM map creation using the hMRI toolbox as well as the scan protocol using the link on the left.